Publisher: Guangdong-Hong Kong-Macao Institute of Central Nervous System Regeneration  

Date: September 11, 2024

A significant advancement in understanding the relationship between physical exercise and mental health has been made by the tension research group at the Guangdong-Hong Kong-Macao Institute of Central Nervous System Regeneration at Jinan University. Their recent study, published in the prestigious journal Cell Metabolism, is titled Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience. 

(Screenshot of the paper)

The research reveals how exercise enhances synaptic structure and function, effectively alleviating anxiety mechanisms triggered by stress. This groundbreaking work sheds light on the metabolic-cerebral mechanisms involved in the benefits of physical activity for mental health.

The paper's independent corresponding author, Prof. Zhang Li, acknowledges the contributions of the co-first authors: Yan Lan, a doctoral graduate from Jinan University, and Wang Yajie, a current doctoral student. Their research was conducted under the guidance of Academician Su Guohui at the Key Laboratory of Central Nervous System Regeneration, affiliated with the Ministry of Education of Jinan University, and was supported by funding from major national science and technology projects.

For those interested in the full research article, it is available at the following link: [Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience] (https://doi.org/10.1016/j.cmet.2024.07.018).