Authors: HU Huifang, HE Qingyu

Publisher: College of Life Science and Technology

Date: June 28, 2024

Colon cancer (CRC) remains a significant contributor to global cancer-related mortality, with metastasis and drug resistance posing significant challenges to effective treatment outcomes. Addressing these critical issues, Professor He Qingyu and Associate Researcher Hu Huifang of Jinan University's Cikkege of Life Science and Technology have elucidated a groundbreaking discovery regarding the role of PRDM16-DT, a novel protein encoded by lncRNA, in driving colorectal cancer metastasis and drug resistance.

The findings, recently published in the esteemed journal Theranostics (IF: 12.4), shed light on the molecular mechanisms underlying CRC metastasis and drug resistance. By investigating the functions of PRDM16-DT, the study identifies potential biomarkers and therapeutic targets vital for enhancing the diagnosis and treatment of CRC, with promising translational implications for clinical application.

(Screenshot of the paper)

Notably, the research introduces a potential therapeutic intervention in the form of Cimicifugoside H-1, a drug demonstrated to effectively attenuate the expression of PRDM16-DT. Through comprehensive cellular and animal studies, the efficacy of Cimicifugoside H-1 in inhibiting tumor metastasis and overcoming CRC chemotherapy resistance is substantiated, offering a promising avenue for tackling tumor resistance in future clinical settings.

Professor He Qingyu and Associate Researcher Hu Huifang, both esteemed scholars from Jinan University, serve as co-corresponding authors of this groundbreaking study, positioning their research at the forefront of innovative advancements in colorectal cancer research and treatment.

Reference:

Hu HF, Han L, Fu JY, He X, Tan JF, Chen QP, Han JR, He QY. LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance. Theranostics. 2024; 14(8):3317-38.

Original Article Link: [Theranostics Article] (https://www.thno.org/v14p3317.htm)