Author: Yang Su 

Pulisher: Guangdong-Hong Kong-Macao Central Nervous System Regeneration Research Institute

Date: May 21, 2024 

In a landmark study that promises to revolutionize our understanding of Huntington's disease (HD), the pioneering research team led by Yang Su and Li Xiaojiang from the Guangdong-Hong Kong-Macao Central Nervous System Regeneration Research Institute at Jinan University has uncovered the pivotal role of HAP40 in modulating mutant huntingtin aggregation and toxicity in HD mice. Their groundbreaking research, detailed in the research paper titled HAP40 modulates Mutant Huntingtin aggregation and toxicity in Huntington's disease mice, was recently published in the prestigious international journal Cell Death & Disease, renowned for its exceptional impact factor of 9.0.

(Screenshot of the paper)

Chen Laiqiang and Qin Yiyang, accomplished doctoral students from Jinan University, stand as co-first authors of the paper, working in tandem with Researcher Yang Su and Professor Li Xiaojiang, who serve as co-corresponding authors. Their collaborative efforts have resulted in a seminal contribution to the field of neurodegenerative disorders, offering new insights into the molecular mechanisms underpinning HD and paving the way for innovative treatment modalities.

For further exploration of this trailblazing research, interested parties can access the original paper through the following link: https://www.nature.com/articles/s41419-024-06716-4. 

This seminal study holds profound implications for elucidating the molecular complexities of HD and opens new avenues for targeted therapeutic interventions that aim to alleviate the burden of this devastating neurodegenerative disorder.