Publisher: Biomedical Translational Research Institute 

Date: April 29, 2024

A groundbreaking collaborative effort between Researcher Yang Meixiang and Professor Yin Zhinan from the Biomedical Transformation Research Institute at Jinan University has yielded significant insights into T cell metabolic regulation and its impact on IL-17 mediated autoimmune diseases. Their research paper, titled Lkb1 Orchestrates, was recently published in the prestigious immunology journal Cell Mol Immunol γδ. Yang Meixiang and Yin Zhinan serve as the co-corresponding authors of this pivotal study.

(Screenshot of the paper)

The paper features a team of talented researchers, including postdoctoral researcher Xiao Zhiqiang, doctoral students Wang Shanshan and Luo Liang, and master's student Lv Wenkai, who collectively contributed as co-first authors. Their collaborative efforts have shed light on the intricate mechanisms underlying T cell metabolism and functional fitness, offering new avenues for controlling autoimmune diseases driven by IL-17.

This research endeavor was made possible through the generous support of various funding sources, including the National Natural Science Foundation of China (82271754, 82071737, 32000615), the Guangdong Provincial Basic and Applied Basic Research Foundation (2020A151511081, 2023A1515012582, 2022A1515110217), and the 111 Project (B16021). These funding initiatives have played a crucial role in advancing scientific knowledge and facilitating innovative research in the field of immunology.

The publication of this research paper not only contributes to the growing body of knowledge on T cell metabolism but also holds significant implications for the development of novel therapeutic strategies for autoimmune diseases. The original link to the paper is available at doi: 10.1038/s41423-024-01163-9, providing researchers and enthusiasts with access to this seminal work in the field of immunology.