Publisher: School of Pharmacy 

Date: January 17, 2024

In a groundbreaking development, researchers at the State Key Laboratory of JNU have unveiled a novel approach for the precise characterization of organic molecules. This cutting-edge method, detailed in a recent publication in the esteemed chemistry journal Chem, promises to revolutionize the field of molecular structure analysis.

Traditional techniques, such as single crystal X-ray diffraction technology, have long been relied upon to determine the three-dimensional structure of crystalline compounds. However, challenges arise when attempting to characterize molecular structures of compounds with irregular crystalline properties, such as low melting point oily substances and trace abundance natural products. These difficulties stem from the limitations in obtaining appropriately sized and well-diffracted single crystals for analysis.

To address these limitations, collaborative efforts between the teams of Professor Li Dan and Lu Weigang from the School of Chemistry and Materials Science, along with Professor Ye Wencai and Wang Ying from the School of Pharmacy at JNU, have led to the development of a groundbreaking method that enhances the crystallization of organic compounds. This innovative approach enables researchers to accurately determine the single crystal structures of a wide range of compounds, overcoming previous challenges in molecular structure analysis.

(Screenshot of the paper)

The research findings, titled Crystal mate for structure elucidation of organic molecules, have garnered international recognition and have been published in the prestigious journal Chem. Dr. Song Jianguo spearheaded this research as the first author, with Professors Li Dan, Lu Weigang, Ye Wencai, and Wang Ying serving as co-corresponding authors. The project received support from various funding sources, including the National Natural Science Foundation of China, the Pearl River Talent Plan Local Innovative Research Team Project, and other key research initiatives.

For more information, the full article can be accessed at:

https://authors.elsevier.com/a/1iNW68jWHEHSbg

https://doi.org/10.1016/j.chempr.2023.12.004