Publisher: Guangdong-Hong Kong-Macao Central Nervous System Regeneration Research Institute 

Translator: YIN Peng 

Date: January 11, 2024

In a landmark discovery that promises to reshape our understanding of neurotoxicity mechanisms, the trailblazing research team led by Li Xiaojiang and Yin Peng from the prestigious Guangdong Hong Kong Macao Institute of Central Nervous Regeneration at JNU has unveiled a groundbreaking research achievement. Their seminal paper, titled Loss of TDP-43 Mediates Severe Neurotoxicity by Suppressing PJA1 Gene Transcription in the Monkey Brain, has been published in the esteemed journal Cellular and Molecular Life Sciences, renowned for its impact factor of 8.0.

(Screenshot of the paper)

The driving force behind this transformative research endeavor, Li Xiaojiang and Yin Peng, have shed light on the intricate interplay between TDP-43 and neurotoxicity in the primate brain, offering unprecedented insights into the underlying molecular mechanisms governing neuronal health and disease progression. Spearheading this pioneering study is Zhu Longhong, a doctoral student at JNU, who serves as the first author of the groundbreaking research paper.

The collaborative efforts of Professor Li Xiaojiang and Researcher Yin Peng from the Guangdong Hong Kong Macao Institute of Central Nervous Regeneration at JNU have culminated in a research breakthrough that holds immense promise for advancing the frontiers of neuroregeneration research. This pivotal work, supported by prestigious funding bodies including the National Natural Science Foundation of China, the National Key Research and Development Program, the Guangdong Provincial Natural Science Foundation, the Guangzhou Science and Technology Program, and JNU, underscores the critical importance of interdisciplinary collaboration in unraveling the complexities of neurological disorders.

For a comprehensive exploration of this groundbreaking research study, readers are encouraged to access the original paper through the DOI link: [DOI: 10.1007/s00018-023-05066-2] (https://doi.org/10.1007/s00018-023-05066-2).