Date: March 21, 2022

Source: School of Medicine

Author: Guo Jinghui

Prof. Guo Jinghui's team in JNU's School of Medicine, in cooperation with the JNU's Institute of Photonics Technology and the Department of Biomedical Engineering at the Hong Kong Polytechnic University (PolyU), has reported progress in improving photogenetic technology by photonic nanojet. Its paper, Photonic Nanojet-Mediated Optogenetics, has been published in the international journal Advanced Science (IF=16.81). The first authors are Guo and Wu Yong, a postgraduate student in JNU's School of Medicine. The corresponding authors are Guo; Prof. Zhang Yao and Associate Prof. Li Yuchao of the institute of Photonics Technology; and Prof. Sun Lei of PolyU's Department of Biomedical Engineering. JNU is the first corresponding unit.

(Screenshot of the paper)

Optogenetics has been widely recognized as the most powerful tool for neuromodulation in the last decade, providing a significant boost to neuroscience research. This research achieves effective optogenetic stimulation at low optical power density, thus reducing off-target effects of optogenetics and greatly improving its spatial resolution. It is expected to be applied in exploring of specific neurons based on photogenetic techniques.

Link to paper: https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202104140