Date: Aug. 4, 2020
Source: Guangdong-Hong Kong-Macao Institute of CNS Regeneration (GHMICR)
Author: Yang Weili
Researcher Li Xiaojiang's team in JNU's Guangdong-Hong Kong-Macao Institute of CNS Regeneration published a research paper online in Proceedings of the National Academy of Sciences of the United States of America (PNAS), a prestigious international academic journal, on Aug. 4. The paper, titled Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice, reveals the selective neurodegeneration mechanism in Huntington disease (HD).
 
 

The paper is the sixth published by Li's team in 2020. Postdoctoral researcher Liu Qiong and doctoral researcher Cheng Siying of Xiangya Hospital Central South University are co-first authors; Li is corresponding author. The research was supported by National Natural Science Foundation of China.
Five other research papers published this year also applied the mouse model to studying the pathological mechanisms of HD and neurodegenerative diseases. (Yang et al., Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4411-4417; Liu et al, Nat Commun. 2020 Feb 27;11(1):1101; Yin et al., EMBO Rep. 2020 Jun 4;21(6):e49783; Yang et al., Nat Commun. 2020 May 22;11(1):2582; Chen et al., Front Cell Neurosci. 2020 Jun 4;14:125)
(Link to article: https://www.pnas.org/content/early/2020/07/30/2002283117)