Date: Aug. 10, 2020
Source: College of Life Science and Technology
He Qingyu and Li Bin, students in JNU’s College of Life Science and Technology, jointly published their paper “Direct targeting of CREB1 with imperatorin inhibits TGFβ2-ERK signaling to suppress esophageal cancer metastasis” in the journal Advanced Science (IF=15.84) in July. The paper made an in-depth analysis of transforming growth factor beta (TGFβ2)’s important role in the metastasis of esophageal cancer from three aspects: biological function, molecular mechanism and potential clinical significance. By high throughput screening, it also found that imperatorin, a kind of small molecular drug, can significantly inhibit tumor metastasis.
 
Associate researcher Xu Wenwen and postgraduate Huang Zhihao from the college the co-first authors; He, Li and Xu are the corresponding authors.
This research is supported by the National Key R&D Program of China (Grant No. 2017YFA0505100), the National Natural Science Foundation of China (Grants No. 81803551, 81973339, 31770888, 81672953, and 81773085), the Guangdong Provincial Innovation and Entrepreneurship Project (Grant No. 2013Y113) and the Zhuhai Innovation and Entrepreneurship (Grant No. ZH01110405160015PWC)
Link to paper:
https://onlinelibrary.wiley.com/doi/10.1002/advs.202000925